• CLICK HERE to download a project proposal form. When you click on this link, an MS Word form will download to your computer to a location determined by your web browser. The form will not open automatically.
• Open the form (named CIVM_Proposal_03_08.doc) in MS Word. Use this form to briefly describe the project and resources you require from the Center, if known at this time. Or indicate that you need help to determine an appropriate imaging strategy.
• Return the form as an e-mail attachment to sally.zimney@duke.edu (919 684-7758). Sally can also answer any questions you have as you fill out the form.

Due to the large number of project proposals, we cannot fulfill all requests. Funded projects take priority, but a limited number of unfunded pilot projects are supported each quarter, which we limit to a maximum of 15 hours on any one of our imaging systems.

We evaluate pilot and funded projects according to the fundamental criteria listed below. We ask, does the project . . .

• Reflect good science?   
• Use the Center's resources effectively?  
• Show potential for growth?

Cost

All charges for CIVM resources are determined in accordance with policies outlined by the NIH Office of Management and Budget for operation of educational animal resources (circular a21).

These charges cover capital equipment replacement, service contracts, expendables such as cryogens, and staff who operate and maintain the equipment. Animal setup, support, and maintenance are charged by the hour. Surcharges are included, if a project involves high-cost expendables (such as hyperpolarized gas or contrast agents).

Basic rates for scanning per hour	Cost		Surcharges	Cost
MR microscopy	$255		Live animal surcharge per hour	$130
micro-CT	$180		Hyperpolarized gas per experiment	$665
micro x-ray	$180
Other services (call 919 684-7758)			Post-processing analysis
			Vitrea workstation Volocity workstation Visualsonics workstation	$50/hr

Responsibilities of a collaborator

We have a limited number of requirements that all collaborators agree to once a project is approved, which are essentially expected in any scholarly exchange:

• We have an implicit assumption that collaborators will seek to publish their results in a peer-reviewed publication.
• Collaborators need to consult members of CIVM who contribute to the completion of a project, and who may serve as possible co-authors.
• Publications must credit the federal grant support the Center receives. Contact Sally Zimney (919 684-7758) for appropriate wording.
• Colleagues in the Center need to review manuscripts at least 2 weeks prior to submission.
• Collaborators need to supply digital copies of publications to the Center for our archives and for inclusion in annual reports to our funding agencies.

Collaborations with the Center continue to grow with researchers from various Duke departments, local and national academic institutions, government agencies, and private industry with applications to disciplines like molecular and cell biology, pulmonary medicine, cardiology, neurobiology, oncology, teratology, and cell biology. The list below includes just some of our 2007-2008 collaborations (Duke-affiliated unless otherwise indicated).

Investigator/institution Project Title Jacopo Annese/Brain observatory, UCSD Profiling of cortical areas by micro-MRI Richard Auten/Neonatal Research Institute Perinatal air pollutant disruption of postnatal airway development Vytas Bankaitis/Cell & Developmental Biology High-resolution MRI of PITPa Nullizygous mice with defects in axonal pathfinding Brian Berridge/GlaxoSmithKline Micro-CT of cardiac function in the CD rat with dobutamine challenge Bennitt Chin/Radiology MR imaging of cardiac function Thomas Coffman/Nephrology Angiotensin receptors and Prostaglandin E2 in regional blood flow in mouse kidney M Dewhirst/Radiation Oncology Ultrasound measurement of tumor microcirculation and perfusion Beverly Fermor/Orthopaedic Bioengineering DNA damage and markers in a spontaneous model of osteoarthritis  Gerald Grant/Neurosurgery In vivo MR permeability in mouse xenograft model of glioblastoma multiforma Timothy Haystead/ Pharma-cology, Cancer Biology Blood flow in lung, brain, heart, kidney in wild-type mice using in situ contrast Joanna Jankowsky, CalTech High-resolution ex vivo imaging of an Alzheimer's mouse model Elizabeth Lacey/UNC-Greensboro NIR-reflectance plasticity in Plantago lanceolata flowers Trygve Leergaard/Univ. Oslo Structural and functional characterization of neural network alterations in transgenic rat model of Huntington's disease Kam Leong/Biomedical Eng Tracking of quantum dots in oral gene delivery Victor Leitao/Urology/Surgery Correlation between shockwave lithotripsy-induced renal injury and crystal deposition in rat kidney using MR Jeffrey Meyer/Radiation Oncology Hypofractionated stereotactic radiotherapy with vascular targeting in an animal model Ashley Manzoor/Med Physics/ Radiation Oncology Functional imaging as a prognostic indicator for Dox-LTSL+hyperthermia treatment in an upcoming clinical trial for locally advanced breast cancer Srini Mukundan/Radiology High-resolution vascular imaging in small animals M Nahrendorf/ MA Gen Hospital CT imaging of murine myocardial infarction Rendon Nelson/Radiology Immunotherapeutic potentiation of an anti-tumor vaccine with radiofrequency ablation with MR 7T imaging Kathy Nightingale/BME Ultrasonic stiffness imaging of rat liver Jonathan Nissanov/Drexel Mouse atlasing Scott Palmer/Pulmonary Med Host defense mechanisms in chronic lung disease Claude Piantadosi/Pulmonary Medicine Effects of hypobaric exposure on cardiac function using ultrasound Howard Rockman/Cardiology Myocardial perfusion in GSNOR knockout mice W. Paul Segars/Advanced Imaging Labs) Development of a 3D rat digital phantom Scott Soderling/Cell Biology WRP as a candidate mental retardation associated gene    Herman Staats/Pathology Distribution and clearance of nasal vaccines Kathleen Sulik/Center for Alcohol Studies, UNC MR and diffusion tensor imaging of a mouse FASD model Zeljko Vujaskovic/Radiation Oncology Mechanism of radiation-induced lung injury Warren Warren/Chemistry iMQC pulse sequence design for use on GE scanners   Robert Wechsler-Reya/ Pharmacology, Cancer Biology Imaging of pre-neoplastic lesions in a mouse model of medulloblastoma Melanie Wergin/M Dewhirst, Radiation Oncology Comparision of effects of Pazopanib on tumor angiogenesis, gene expression, drug delivery and antitumor effect with Avastin, Gleevec, and Sutent Robert Wechsler-Reya, (Pharmacology/Cancer Biology Imaging of pre-neoplastic lesions in a mouse model of medulloblastoma Raimond Winslow/Johns Hopkins Population-based 4D cardiac atlas of mouse Hong Yuan/Radiation Oncology Hypoxia and perfusion imaging using microPET with dual imaging agents (62)Cu-PTSM/(62)Cu-ATSM