CIVM

Center for in vivo Microscopy

 
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about us


At the Center for In Vivo Microscopy (CIVM) we create new methods for small animal imaging and apply the tools and techniques we develop to important biomedical questions. The CIVM was established in the Duke University Medical Center Department of Radiology in 1986.

The Center has been fortunate to have support to create an imaging program that covers a broad range of technologies.

Funding
CIVM is a national Biomedical Technology Resource Center funded primarily by the National Institutes of Health, National Center for Research Resources (NCRR) (P41 RR005959). This funding is pending renewal.

Support from the National Cancer Institute (NCI) Small Animal Imaging Resource Program (SAIRP NCI U24 CA092656) helps develop integrated technologies for multi-modality small animal molecular imaging, apply technologies to cancer research, disseminate technologies, and train scientists in use of these technologies. We also have another NCI grant (R21 CA124584, Cristian Badea, PI) to investigate tumor perfusion in small animals with tomographic digital subtraction angiography.

Support from the National Heart, Lung, and Blood Institute (NHLBI) (R21 HL087094, Bastiaan Driehuys, PI), helps us investigate hyperpolarized 129Xe imaging of pulmonary gas exchange.

Additional pulmonary studies are supported through a contract with Merck Frosst to demonstrate the ability of 3He imaging to differentiate the airway hyper-responsiveness phenotype in several mouse models of asthma.

We are one of 6 universities involved in the Mouse Biomedical Informatics Research Network (Mouse BIRN) test bed to study neurodegenerative diseases by pooling multi-modal data from mouse models to investigate neurological disorders. This initiative is funded by NCRR.

A training grant from National Institute of Biomedical Imaging and Bioengineering (NIBIB) with our colleagues in Biomedical Engineering helps support our pre-doctoral students in their first 2 years to undertake a curriculum that provides broad training in medical physics and instrumentation followed by more focused specialized coursework.

Collaborations

Our imaging collaborations touch all areas of biomedical research at international, national, and local levels, with researchers from the federal, university, and industrial sectors. Representative collaborations are summarized in our collaboration link, which also includes instructions here about how to initiate a project with our Center.

 

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