| The Center for In Vivo Microscopy is a national Biomedical Technology Research Center funded by the National Institutes of Health, National Center for Research Resources (NCRR) (P41 RR005959). This funding is starting its 22nd year of renewasl.
This grant is divided into 4 cores, with faculty PIs for each: MR Microscopy (GA Johnson); Functional pulmonary imaging with hyperpolarized gas (B Driehuys); Molecular Imaging Workbench (C Badea);
Integration and developing new small animal imaging methods (L Hedlund).
Support from the National Cancer Institute (NCI) as one of the Small Animal Imaging Resource Programs (SAIRP) (U24 CA092656) helps us develop integrated technologies for multi-modality small animal imaging, to apply and disseminate technologies to cancer researchers, and to train scientists in use of these technologies.
Other members of our team have also secured funding. Dr. Xiaofeng (Steve) Zhang (R21 RR025824) is exploring Resolution Limits for Fluorescence Tomographic Molecular Imaging with support from NCRR.
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As Co-PIs, Drs. Bastiaan Driehuys and Tamara Branca are funded by NCI (R01 CA142842) for pulmonary cancer studies relating to Sensitive and Specific Molecular Imaging of Pulmonary Nodules.
With support from the National Heart, Lung, and Blood Institute (NHLBI) (R01 HL105643), Dr. Driehuys' team is exploring Early Detection of Changes in Pulmonary Gas Exchange by Hyperpolarized Xenon MRI. This study exemplifies translation of preclinical imaging research to clinical studies, with goals to optimize our recently demonstrated capability to image regional gas exchange by 129Xe MRI in human subjects, to use the optimized method to measure and understand resting perfusion heterogeneity, and to demonstrate the sensitivity of this imaging approach to detect changes in regional lung function much earlier than currently possible.
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Funding
