CIVM
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CIVM WIKI
(Duke only)

Journal club

Wednesdays
noon-1 PM

Room 162
Bryan Research Building

info: 919 684-7758


 

Duke Center for In Vivo Microscopy (CIVM) is one of the NIH/NCRR/NIBIB National Biomedical Technology Resource Centers dedicated to developing novel methods for preclinical imaging and applying those methods to important biomedical problems.

Our comprehensive small animal imaging program for the basic sciences includes MRI, CT, x-ray, ultrasound, confocal, optical, and SPECT technologies, all at the highest possible spatial resolution.

nibib logo

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CIVM continues to expand our range of technical capabilities and applications, such as these examples:

Dynamic 4D CT perfusion
Tractography from
40-day-old rat
3Helium mouse lung,
3D isotropic acquisition at 156-micron resolution
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.Selected 2011-2012 publications

CT

C Badea, KK Athreya, G Espinosa, DP Clark, AP Ghafoori, Y Yi, DG Kirsch, GA Johnson, A Annapragada, KB Ghaghada, Computed tomography imaging of primary lung cancer in mice using a liposomal-iodinated contrast agent, PLoS ONE 7(4): e34496, 2012 Open access

C Badea, X Guo, D Clark, et al. Dual energy micro-CT of the rodent lung, Am J Physiol - Lung Cell and Mol Physiol, March 16 2012 (Epub)

X Guo, SM Johnston, Y Qi, GA Johnson, CT Badea, 4D Micro-CT using Fast Prospective Gating, Phys Med Biol, 57(1): 257–271, 2012

CT Badea, LW Hedlund, J Cook, et al., Micro-CT imaging assessment of dobutamine-induced cardiac stress in rats, J Pharma Tox Methods 63(1):24-29, 2011

CT Badea, SM Johnston, Y Qi, GA Johnson, 4D micro-CT for cardiac and perfusion applications with view under sampling, Phys Med Biol 56(11):3351-3369, 2011

Lin M, Qi Y, Chen AF, Badea CT, Johnson GA. Phenylephrine-modulated cardiopulmonary blood flow measured with use of x-ray digital subtraction angiography. J Pharmacol Toxicol Methods, 64(2):180-6, 2011

MR - BRAIN STUDIES / ATLASES

C Liu W Li, B Wu, Y Jiang, GA Johnson, 3D fiber tractography with susceptibility tensor imaging, Neuroimage.59(2):1290-1298, 2012

T Wu, MH Bae, M Zhang, R Pan, A Badea. A prior feature SVM-MRF based method for mouse brain segmentation, Neuroimage. 59(3):2298-306, 2012

DM Bowden, GA Johnson, L Zaborsky, et al., A symmetrical Waxholm canonical mouse brain for NeuroMaps, J Neurosci Meth 195(2):170-175, 2011

M Hawrylycz, RA Baldock, A Burger, T Hashikawa, GA Johnson, et al. Digital atlasing and standardization in the mouse brain, PLoS Comp Biol, 7(2): e1001065, 2011 Free PMC article

Y Jiang, GA Johnson, Microscopic diffusion tensor atlas of the mouse brain, NeuroImage 56(3): 1235-1243, 2011 Supplemental data

GA Johnson, A Badea, Y Jiang, Quantitative neuromorphometry using MR histology, Toxicol Pathol 39(1):85-91, 2011

M Poot, A Badea, RW Williams, MJ Kas, Identifying human disease genes through cross-species gene mapping of evolutionary conserved processes, PLoS ONE. May 4;6(5):e18612, 2011 Free PMC article

MR - OTHER STUDIES

L Xie, RE Cianciolo, B Hulette, HW Lee, Y Qi, G Cofer, GA Johnson, Magnetic resonance histology of age-related nephropathy in the Sprague Dawley rat, Toxicologic Pathology 2012 Apr 13 [Epub ahead of print]

D Perperidis, E Bucholz, GA Johnson, C Constantinides, Morphological studies of the murine heart based on probabilistic and statistical atlases. Comput Med Imaging Graph 36:119-129, 2012

MR PULMONARY HYPERPOLARIZED GAS STUDIES

ZI Cleveland, HE Moller, LW Hedlund, JC Nouls, MS Freeman, et al. In vivo MR imaging of pulmonary perfusion and gas exchange in rats via continuous extracorporeal infusion of hyperpolarized 129Xe. PLoS ONE 7(2): e31306, 2012, Open access

B Driehuys, S Martinez-Jimenez, ZI Cleveland, et al. COPD: safety and tolerability of hyperpolarized 129Xe MR imaging in healthy volunteers and patients, Radiology 262(1):279-289, 2012

AC Thomas, SS Kaushik, J Nouls, EN Potts, DM. Slipetz, WM Foster, B Driehuys, Effects of corticosteroid treatment on airway inflammation, mechanics, and hyperpolarized 3He MRI in an allergic mouse model, J Appl Physiol, 2012 Jan 12 [Epub] - Invited editorial about article: “Editor’s Picks” T Winkler JG Venegas Are all airways equal? [Epub before print]

SS Kaushik, ZI Cleveland, GP Cofer, et al., Diffusion weighted imaging of hyperpolarized 129Xe in patients with COPD, Magn Reson Med 65(4):1154-1165, 2011

J Nouls, M Fanarjian, L Hedlund, A constant-volume ventilator and gas recapture system for hyperpolarized gas MRI of mouse and rat lungs, Concepts in Magn Reson Part B 39B(2):78-88, 2011 Supplemental data

OPTICAL

X Zhang, CT Badea, Highly efficient detection in fluorescence tomography of quantum dots using time-gated acquisition and ultrafast pulsed laser, Proc Soc Photo Opt Instrum Eng. 7896, pii: 78962W, 2011 Free PMC Article

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